【博士研究生导师、硕士研究生导师】张辉 教授

张辉，男，博士研究生导师、硕士研究生导师。兵团中青年科技创新领军人才，兵团高等学校优秀青年教师，兵团英才第二层次。中国畜牧兽医学会动物传染病学流行病学专业组常委。现任石河子大学动物科技学院院长。

一、教育经历：

2002年在山东农业大学本科毕业，2005年在新疆农业大学获得硕士学位；2009年在石河子大学获得博士学位。

二、导师资格

博士研究生导师、硕士研究生导师

三、主要研究内容

人兽共患病致病机制与防控；生物分子结构与功能、功能基因组学研究；新型检测技术和疫苗的产品研发。

四、近三年主持的主要科研项目

(1) 国际科技合作重点项目，新型布鲁氏菌病鉴别诊断技术的联合研发。

(2) 国家自然基金，布鲁氏菌感染宿主细胞过程中NF-κB调控细胞凋亡的分子机制。

(3) 国家自然基金，布鲁氏菌外膜蛋白OMP25对宿主细胞自噬/凋亡信号通路的调控机制研究。

(4) 国家重点研发计划子课题，布鲁氏菌毒力蛋白对宿主关键分子调控机制研究。

五、近三年发表论文（作为通讯作者）

(1) Deletion of the Type IV Secretion System Effector VceA Promotes Autophagy and Inhibits Apoptosis in Brucella-Infected Human Trophoblast Cells. Current Microbiology, 2019, DOI 10.1007/s00284-019-01651-6.

(2) Expression and functional analysis of Brucella outer membrane protein 25 in recombinant goat pox virus. MOL MED REP, 2019, 19: 2323-2329.

(3) Brucella abortus phosphoglyceromutase and dihydrodipicolinate reductase induce Th1 and Th2-related immune responses. World J Microbiol Biotechnol, 2018, 34(22): 1-8.

(4) Development and evaluation of in murine model, of an improved livevaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant. Microbial Pathogenesis, 2018, 124 (2018): 250-257.

(5) Outer Membrane Protein 25 of Brucella Activates Mitogen-Activated Protein Kinase Signal Pathway in Human Trophoblast Cells. Front. Vet. Sci. 2017, 4:197.

(6) Transcriptional regulator GntR of Brucella abortus regulates cytotoxicity, induces the secretion of inflammatory cytokines and affects expression of the type IV secretion system and quorum sensing system in macrophages. World J Microbiol Biotechnol, 2017, 33:60.  

(7) Deletion of the transcriptional regulator GntR down regulated the expression of Genes Related to Virulence and Conferred Protection against Wild-Type Brucella Challenge in BALB/c Mice. 2017, Molecular Immunology, 92 (2017): 99-105.

(8) Brucella abortus 2308 DNodVDNodW double-mutant is highly attenuated and confers protection against wild-type challenge in BALB/c mice. Microb Pathogenesis, 2017, 106: 30-39.

(9) Construction and Characteristic Analysis of Omp10 Deletion Mutant of Brucella abortus. Pakistan J. Zool., 2017, 49(5): 1809-1816.

(10) Brucella melitensis M5-90△bp26 as a potential live vaccine that allows for the distinction between natural infection and immunization. Canadian journal of microbiology. 2017, 63(8): 719-729.

六、联系方式

电子邮箱：604118228@qq.com；联系电话：0993-2057970